Corneal Tomography in Patients Undergoing LASIK with Femtosecond Laser: Preoperative and 3-Month Postoperative Study
DOI:
https://doi.org/10.71413/ctyd3w08Keywords:
Pentacam, LASIK, Topography, Elevation, PachymetryAbstract
Relevance: The study of corneal topography is essential in the preoperative assessment of Laser-Assisted In Situ Keratomileusis (LASIK). A new standardized method for the analysis of topographic maps would be useful to help ensure a successful surgical outcome.
Purpose: To design a new standardized method for the analysis of tomographic maps and use it to compare the maps of patients before undergoing LASIK surgery with femtosecond laser and three months after the procedure.
Methods: A total of 50 eyes from 25 patients were selected for the study. All had available tomographic data both before surgery and three months postoperatively. From these tomographies, data were extracted at 17 predefined corneal points, consistently located on each map: the coordinate origin, and at 1, 2, 3, and 4 mm in the temporal, nasal, inferior, and superior directions. These data were compiled in an Excel spreadsheet for further analysis. The corneal maps selected for evaluation included curvature, anterior elevation, and pachymetry.
Results: Statistically significant differences (p < 0.05) were found between preoperative and postoperative values across the entire anterior curvature map and only in the temporal area of the posterior curvature map. In pachymetry, significant differences were observed throughout the map except at 4 mm from the coordinate origin. Moreover, a strong correlation was identified between pre-postoperative differences in the anterior curvature maps' radius and the corrected spherical equivalent (greater ablation yielded greater differences), while only a weak correlation was found in pachymetric changes.
Conclusions: This study proposes a novel measurement approach for the analysis of tomographic maps, based on predefined and consistently used corneal points. This method enables a more precise and standardized evaluation of the corneal surface compared to previously available methodologies.
References
Farjo AA, Sugar A, Schallhorn SC, Majmudar PA, Tanzer DJ, Trattler WB, et al. Femtosecond lasers for LASIK flap creation: a report by the American Academy of Ophthalmology. Ophthalmology 2013; 120(3):5–20. DOI: https://doi.org/10.1016/j.ophtha.2012.08.013
Kahuam-López N, Navas A, Castillo-Salgado C, Graue-Hernandez EO, Jimenez- Corona A, Ibarra A. Femtosecond laser versus mechanical microkeratome use for laser- assisted in-situ keratomileusis (LASIK). Cochrane Database Syst Rev 2018; 2. DOI: https://doi.org/10.1002/14651858.CD012946
Xia LK, Yu J, Chai GR, Wang D, Li Y. Comparison of the femtosecond Laser and mechanical microkeratome for flap cutting in LASIK. Int J Ophthalmol 2015; 8(4):784-790.
Kim CH, Song JH, Na KS, Chung SH, Joo C-K. Factors Influencing Corneal Flap Thickness in Laser In Situ Keratomileusis with a Femtosecond Laser. Korean J Ophthalmol 2011;25(1):8-14. DOI: https://doi.org/10.3341/kjo.2011.25.1.8
Gimbel HV, Penno EE. Complicaciones en LASIK. In: Peters T, Iskander N. Barcelona: ESPAXS S.A; 2003.
American Academy of Ophthalmology. Cirugía refractiva. Curso de ciencias básicas y clínicas. Sección 13. Barcelona: ELSEVIER España S.L; 2009
Zheng Y, Zhou Y, Zhang J, Liu Q, Zhai C, Wang Y. Comparison of laser in situ keratomileusis flaps created by 2 femtosecond lasers. Cornea 2015; 34:328–333. DOI: https://doi.org/10.1097/ICO.0000000000000361
Li X, Wang Z, Cao Q, Hu L, Tian F, Dai H. Pentacam could be a useful tool for evaluating and qualifying the anterior chamber morphology. Int J Clin Exp Med 2014; 7(7):1878-1882
Al-Ageel S, Al-Muammar AM. Comparison of central corneal thickness measurements by Pentacam, noncontact specular microscope, and ultrasound pachymetry in normal and post-LASIK eyes. Saudi J Ophthalmol 2009; 23: 181–187. DOI: https://doi.org/10.1016/j.sjopt.2009.10.002
Dong J, Tang M, Zhang Y, Jia Y, Zhang H, Jia Z, Wang X. Comparison of anterior segment biometric measurements between Pentacam HR and IOLMaster in normal and high myopic eyes. PLoS ONE 2015:10(11):1-10. DOI: https://doi.org/10.1371/journal.pone.0143110
McAlinden C, Khadka J, Pesudovs K. A comprensive evaluation of the precision (repeatability and reproducibility) of the Oculus Pentacam HR. Invest Ophthalmol Vis Sci 2011; 52(10). DOI: https://doi.org/10.1167/iovs.10-7093
Piñero D, González CS, Alió JL. Intraobserver and interobserver repeatability of curvature and aberrometric measurements of the posterior corneal surface in normal eyes using Scheimpflug photography. J Cataract Refract Surg 2009; 35:113–120. DOI: https://doi.org/10.1016/j.jcrs.2008.10.010
Li H, Chen M, Tian L, Li DW, Peng YS, Zhang FF. Study on the change of optical zone after femtosecond laser assisted laser in situ keratomileusis. Zhonghua Yan Ke Za Zhi 2018 Jan 11; 54(1):39-47.
Huang JH, Ge LN, Wen DZ, Chen SH, Yu Y, Wang QM. Repeatibility and agreement of corneal thickness measurement with Pentacam Scheimpflug protography and Visante optical coherence tomography. Zhonghua Yan Ke Za Zhi 2013 Mar; 49(3):250-256.
Xu Z, Peng M, Jiang J, Yang C, Zhu W, Lu F, Shen M. Reliability of Pentacam HR thickness maps of the entire cornea in normal, post-laser in situ keratomileusis, and keratoconus eyes. Am J Ophthalmol 2015. DOI: https://doi.org/10.1016/j.ajo.2015.11.008
Queirós A, Villa-Collar C; Morim-de-Sousa A; Gargallo B; Gutiérrez AR; González- Méijome JM. Corneal morphology and visual outcomes in LASIK patients after orthokeratology and soft lens wear: a pilot study. Presentado en XXXV Congress of the ESCRS Lisbon, 2017. DOI: https://doi.org/10.1016/j.clae.2018.09.001
Khairat YM, Mohamed YH, Moftah I ANO, Fouad NN. Evaluation of corneal changes after myopic LASIK using the Pentacam. Clin Ophthalmol 2013; 7: 1771–1776. DOI: https://doi.org/10.2147/OPTH.S48077
Ciolino JB, Belin MW. Changes in the posterior cornea after laser in situ keratomileusis and photorefractive keratectomy. J Cataract Refract Surg 2006; 32:1426– 1431. DOI: https://doi.org/10.1016/j.jcrs.2006.03.037
Pérez-Escudero A, Dorronsoro C, Sawides L, Remón L, Merayo-Lloves J, Marcos S. Minor influence of myopic laser in situ keratomileusis on the posterior corneal surface. Invest Ophthalmol Vis Sci 2009; 50:4146–4154 DOI: https://doi.org/10.1167/iovs.09-3411
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